Registries & Trials

To support its continuing efforts to enhance patient care, the Society strongly encourages its members to participate in research and clinical trials. The Society has served and will continue to serve as a sponsor/co-sponsor of registries/trials, when deemed appropriate. Links to information on additional registries and clinical trials, as well as resources designed to assist surgeons interested in participating in such efforts, are listed below.

Society-Sponsored Registries and Research Studies

• Idiopathic Granulomatous Mastitis Registry

  Status: Closed to Accrual

  Background. Idiopathic granulomatous mastitis (IGM) is an uncommon inflammatory condition that requires specialized care. Etiology is unclear and medical and surgical management is complicated. There is a paucity of high-quality literature on its treatment. These patients often get discussed on the ASBRS Forums with mixed recommendations. It is a problem the membership has to treat without consensus on the best treatments. The purpose of this registry trial to be able to collect data on a large cohort of patients across multiple institutions to identify the most efficacious ways to treat this condition. Learn More.

• COVID-19 Registry

  Status: Completed

  Background. The COVID-19 pandemic rapidly altered health care worldwide. To save protective equipment and minimize exposures, hospitals stopped some or all cancer surgery, leading oncologic providers to quickly adjust patient management. The goal of this study was to describe the breast cancer patient level changes which occurred during the initial months of COVID-19 in the United States. View full publication:

  1. Wilke, L.G., Nguyen, T.T., Yang, Q. et al. Analysis of the Impact of the COVID-19 Pandemic on the Multidisciplinary Management of Breast Cancer: Review from the American Society of Breast Surgeons COVID-19 and Mastery Registries. Ann Surg Oncol 28, 5535–5543 (2021). https://doi.org/10.1245/s10434-021-10639-1.

• Nipple Sparing Mastectomy Registry

  Status: Completed

  Background. The Nipple Sparing Mastectomy Registry (NSMR) was designed to facilitate compiling information on metrics utilized, techniques utilized, aesthetic outcomes, as well as oncologic outcomes of the Nipple Sparing Mastectomy. The registry aimed to provide a large prospective collection of data points specifically gathered to provide evidence-based medicine on outcome measures and metrics utilized for the nipple sparing mastectomy. This was a non-randomized, multicenter, prospective registry based within the Society’s Mastery of Breast Surgery Program. The nipple sparing mastectomy registry successfully enrolled 2,000 patients and closed in May, 2021.

• The CALLER Re-Excision Study

  Status: Completed

  Background. More than 20% of patients undergoing initial breast-conserving surgery (BCS) for cancer require reoperation. To address this concern, the American Society of Breast Surgeons (ASBrS) endorsed 10 processes of care (tools) in 2015 to be considered by surgeons to de-escalate reoperations. In a planned follow-up, we sought to determine which tools were associated with fewer reoperations. View full publications:

  1. Landercasper, J., Attai, D., Atisha, D. et al. Toolbox to Reduce Lumpectomy Reoperations and Improve Cosmetic Outcome in Breast Cancer Patients: The American Society of Breast Surgeons Consensus Conference. Ann Surg Oncol 22, 3174–3183 (2015). https://doi.org/10.1245/s10434-015-4759-x

  2. Landercasper, J., Borgert, A.J., Fayanju, O.M. et al. Factors Associated with Reoperation in Breast-Conserving Surgery for Cancer: A Prospective Study of American Society of Breast Surgeon Members. Ann Surg Oncol 26, 3321–3336 (2019). https://doi.org/10.1245/s10434-019-07547-w

Additional Resources:

Alliance for Clinical Trials in Oncology

NRG Oncology Clinical Trials

ECOG-ACRIN Cancer Research Group

SWOG Cancer Research Network

Western Institutional Review Board (WIRB)

National Cancer Institute Clinical Trials website

Cancer Trials Support Unit (CTSU) protocol listing

ClinicalTrials.gov